Home » Key Scientific Articles » Ultrastructural patterns of the activated cell death programs in the human brain.

Ultrastructural patterns of the activated cell death programs in the human brain.

Pais V, Danaila L, Pais E.

Ultrastruct Pathol. 2013 Apr;37(2):110-20.

Department of Neurosurgery, National Institute of Neurology and Neurovascular Diseases, Bucharest, Romania. [email protected]

 

Abstract

 

The authors analyzed by transmission electron microscopy (TEM) neurosurgical samples obtained from patients with cerebral tumors, neurotrauma, cerebral ischemia, Moyamoya disease, encephalitis, etc. Their observations concern a variety of dying cell types by different programmed deathpathways, including apoptosis, paraptosis, autophagy, autoschizis, programmed necrosis, as well as combined and coexisting forms. This ample work pointed out not only the role of TEM in cell death diagnosis, but the biological differences in cell behavior and beneficial or detrimental effects of suicides for homeostasis, survival, or normal functioning of a tissue, like the integrated vascular tissue and brain parenchyma.

 

Go To PubMed