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Synchronization of Action Potentials During Low Magnesium Induced Bursting

Johnson SE1, Hudson JL2, Kapur J3. J Neurophysiol. 2015 Jan 21:jn.00286.2014.

Show Affiliations

1University of Nebraska Medical Center.

2University of Virginia.

3Univ Virginia Hlth Sci Ctr [email protected]

 

Abstract

The relationship between mono and poly-synaptic strength and action potential synchronization was explored using a reduced external Mg2+ model. Single and dual whole-cell patch-clamp recordings were performed in hippocampal cultures in three concentrations of external Mg2+. In decreased Mg2+ medium, the individual cells transitioned to spontaneous bursting behavior. In lowered Mg2+ media the larger excitatory synaptic events were observed more frequently and fewer transmission failures occurred, suggesting strengthened synaptic transmission. The event  synchronization was calculated for the neural action potentials of the cell pairs and it increased in media where Mg2+concentration was lowered. Analysis of surrogate data where bursting was present, but no direct or indirect connections existed between the neurons, showed minimal  action potential synchronization. This suggests the synchronization of action potentials is a product of the strengthening synaptic connections within neuronal networks.

Copyright © 2014, Journal of Neurophysiology.

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Synchronization of Action Potentials During Low Magnesium Induced Bursting