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Scaffolds for tissue engineering of cardiac valves

Jana S1, Tefft BJ1, Spoon DB1, Simari RD2. Acta Biomater. 2014 ;10(7):2877-93.

1Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.and

2Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: [email protected]

Abstract

 Tissue engineered heart valves offer a promising alternative for the replacement of diseased heart valves avoiding the limitations faced with currently available bioprosthetic and mechanical heart valves. In the paradigm of tissue engineering, a three-dimensional platform – the so-called scaffold – is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical properties of a native valve. This article reviews technological details of the scaffolds that have been applied to date in heart valve tissue engineering research.

Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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Scaffolds for tissue engineering of cardiac valves. Global Medical Discovery