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Novel antibacterial orthodontic cement containing quaternary ammonium monomer dimethylaminododecyl methacrylate.

Melo MA1, Wu J2, Weir MD3, Xu HH4. J Dent. 2014;42(9):1193-201.

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1Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA. Electronic address: [email protected]

2Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA; Department of Prosthodontics, School of Stomatology, Shan Dong University, Jinan 250012, China; Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China.

3Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA.

4Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA. Electronic address: [email protected]

 

Abstract

OBJECTIVES:

Demineralized lesions in tooth enamel around orthodontic brackets are caused by acids from cariogenic biofilm. This study aimed to develop a novel antibacterial orthodontic cement by incorporating a quaternary ammonium monomer dimethylaminododecyl methacrylate (DMADDM) into a commercial  orthodontic cement, and to investigate the effects on microcosm biofilm response and enamel bond strength.

METHODS:

DMADDM, a recently-synthetized antibacterial monomer, was incorporated into orthodontic cement at 0%, 1.5%, 3% and 5% mass fractions. Bond strength of brackets to enamel was measured. A microcosm biofilm model was used to measure metabolic activity, lactic acid production, and colony-forming units (CFU) on  orthodontic cements.

RESULTS:

Shear bond strength was not reduced at 3% DAMDDM (p > 0.1), but was slightly reduced at 5% DMADDM, compared to 0% DMADDM. Biofilm viability was substantially inhibited when in contact with orthodontic cement containing 3% DMADDM. Biofilm metabolic activity, lactic acid production, and CFU were much lower on orthodontic cement containing DMADDM than control cement (p < 0.05).

CONCLUSIONS:

Therefore, the novel antibacterial orthodontic cement containing 3% DMADDM inhibited oral biofilms without compromising the enamel bond strength, and is promising to reduce or eliminate demineralization in enamel around orthodontic brackets.

Published by Elsevier Ltd.

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Figure legend:  The figure shows a schematic drawing of the development of initial caries lesions around orthodontic brackets  promoted by caries-related bacteria acids.  A promising alternative to combat the demineralization around orthodontic brackets is the development of orthodontic bonding agents with antibacterial properties or microbial- repellent actions.

 

Novel antibacterial orthodontic cement containing quaternary ammonium monomer dimethylaminododecyl methacrylate. Global Medical Discovery