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The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.

Perez-Campo FM, Costa G, Lie-a-Ling M, Kouskoff V, Lacaud G.

Immunology. 2013;139(2):161-5.

Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK. [email protected].

 

Abstract

 

The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A(1)) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis.

© 2013 The Paterson Institute for Cancer Research Immunology © 2013 Blackwell Publishing Ltd.

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