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Biology of extreme radiation resistance: the way of Deinococcus radiodurans.

Krisko A, Radman M.

Cold Spring Harb Perspect Biol. 2013;5(7). pii: a012765.

Mediterranean Institute for Life Sciences, 21000 Split, Croatia.

 

Abstract

 The bacterium Deinococcus radiodurans is a champion of extreme radiation resistance that is accounted for by a highly efficient protection against proteome, but not genome, damage. A well-protected functional proteome ensures cell recovery from extensive radiation damage to other cellular constituents by molecular repair and turnover processes, including an efficient repair of disintegrated DNA. Therefore, cell death correlates withradiation-induced protein damage, rather than DNA damage, in both robust and standard species. From the reviewed biology of resistance to radiationand other sources of oxidative damage, we conclude that the impact of protein damage on the maintenance of life has been largely underestimated inbiology and medicine.

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