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Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes

Significance Statement

Renin-angiotensin system (RAS) is now well known as a cardiovascular homeostatic system. However, Renin-angiotensin system is also anything more than one of signal transduction pathways. In cellular level, the ligand and the receptors of RAS are absolutely parts of signal transduction pathways, and their functions are respectively determined by downstream factors of the receptors. This small Renin-angiotensin system is recently called as a local RAS. Local RAS is certainly independent of systemic Renin-angiotensin system in functions; however, it is interesting that local Renin-angiotensin system is partly affected by systemic Renin-angiotensin system since the ligand and the receptors are common. Our study showed that angiotensin II type 1 and 2 receptors have functions to modulate the hypertrophy in chondrocytes. Namely, it was shown that chondrocytes could be influenced by systemic Renin-angiotensin system through the receptors in vivo. Actually, some researchers have reported the statistical relations between hypertension and osteoarthritis. Our novel  knowledge is considered to be important in investigate the details of osteoarthritis in vivo.

 

Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes- global medical discovery

 

 

 

 

 

 

 

 

 

 

 

 

Tsukamoto I, Inoue S, Teramura T, Takehara T, Ohtani K, Akagi M.

FEBS Open Bio. 2013;3:279-84.

Department of Orthopaedic Surgery, Faculty of Medicine, Kinki University, 377-2 Ohno-Higashi, Osaka-Sayama City, Osaka 589-8511, Japan.

 Abstract

A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensinII type 1 receptor (AT1R) and angiotensin II type 2 receptor (AT2R) separately in the cell line ATDC5, which involves differentiation from mesenchymal stem cells to hypertrophic chondrocytes. Activation of AT1R suppressed and activation of AT2R enhanced the expression of markers of hypertrophic differentiation, including type X collagen, matrix metalloproteinase 13 and runt-related transcription factor 2.

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Hypertrophic differentiation of chondrocytes modulation by Angiotensin system first featured on Global Medical Discovery the World’s leading source of medical research news: featuring the innovations that will lead to a brighter tomorrow