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A new animal bioreactor for producing pharmaceutical proteins.

Significance statement

The perspective study “A new animal bioreactor for producing pharmaceutical proteins” indicated that current biotechnology industry is experiencing an extremely shortage for recombinant therapeutic proteins and asked whether we’ll have a new strategy to overcome this bottleneck. The study detailed the advantages and disadvanges of current bioreactors for producing recombinant therapeutic proteins,and proposed a new transgenic animal bioreactor,epididymis, one of the male accessory sex glands, for producing pharmaceutical proteins. Compared with current bioreactor, this new bioreactor secretes artificial proteins into seminal plasma which warrants easy isolation of foreign proteins, possesses various kinds of posttranslational modifications which guarantees the expression of active proteins, provides protection for serected proteins against degradation through the epididymosome (exosome in epididymal lumen), bears no or little relationship to the cycle of the seasons, has no negative impact on animal’s health. In a word, it is a very good bioreactor with the features of heavy output, high quality, low cost, easy extraction, no environmental pollution,doing no harm to animal health, free of season and so on. Thus, epididymis may represent a new promising platform to uncork the biomanufacturing bottleneck for the production of pharmaceutical proteins. Anyone who’s looking for a biomanufacturing system can’t put all their eggs in one basket. When try other bioreactors, why not try epidiymis!

Figure Legend

 Little organ, big function. The organs in animals which have great potentials to excrete proteins into body fluids can be used as natural bioreactors to produce recombinant therapeutic proteins. Bioreactors currently available are mammal gland (first from the above in the figure), liver (second), bladder (third), Vesicular gland (fourth) and epididymis (fifth). And epididymis is newly dicovered bioreactor which may be the best bioreactor available to biomanufacturing industry for the production of pharmaceutical proteins.

A new animal bioreactor for producing pharmaceutical proteins. Global Medical Discovery

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Journal Reference

He J1, Li X2, Luo D3, Zhang C4, Hu S4, Li X5. Acta Biochim Biophys Sin (Shanghai). 2014 ;46(9):826-8.

Show Affiliations

1Department of Pediatrics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China.

2College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China.

3School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China.

4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China.

5Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China [email protected]

Abstract

Current biotechnology industry is experiencing an extremely low manufacturing capacity for recombinant therapeutic proteins. There is an urgent need to improve the pre-existing recombinant protein expression technologies or to develop new protein expression systems to overcome this bottleneck. Among current protein expression systems, transgenic animals, compared with the other platforms, may be an economical and efficient strategy to produce therapeutic proteins. Many transgenic animal bioreactors,such as mammary gland, liver, bladder, ovary, seminal vesicle, are currently available. Among them, mammary gland is currently viewed as the best available bioreactor; however, it is limited by the discontinuous nature of the lactation cycle, and technical difficulties in generating transgenic mammals, adverse effects of certain proteins on animal’s health, and re-absorption of some of the proteins and so on. Thus, we here propose that epididymis, one of the male accessory sex glands, for having many advantages over mammary gland and other systems, may represent a very promising new transgenic animal bioreactor for the production of pharmaceutical proteins.

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