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Influence of surface properties of zinc oxide nanoparticles on their cytotoxicity

Significance Statement

 

Nanobiotechnology Group at Yeditepe University (http://nanobio.yeditepe.edu.tr) lead by Prof. Dr. Mustafa Culha focuses on living-nonliving interactions and contains elements from chemistry, material science, nanoscience, nanotechology and medicine. The group employs variety techniques including spectroscopic and imaging.  Dr. Culha and his group have been involved in Seventh Framework Programme in a collaborated project called “Mitigation of risk and control of exposure in nanotechnology based inks and pigments” (NANOMICEX) (http://nanomicex.eu) since 2012. The concept of NANOMICEX stems from the need of ensuring the safety of workers dealing with the production or handling of the engineered nanoparticles employed in the pigment/ink industry due to the need of providing the workers with integrated, cost effective and appropriate strategies to control the exposure to engineered nanoparticles. Dr. Culha’s group has been enrolled in this project to reduce the potential risk upon worker’s exposure to engineered nanoparticles through the modification of nanoparticles with effective surface modifiers (obtain less hazardous NPs) and development of novel methods based on nanoparticle biofunctionalization.  The knowledge about hazard properties and exposure potential of NPs will be improved and their effectiveness of the personnel protective equipment, ventilation, filtration and other control systems will be enhanced within this project.

Influence of surface properties of zinc oxide nanoparticles on their cytotoxicity. Global Medical Discovery

 

 

 

 

 

 

 

 

 

 

 

 

 

Journal Reference

Altunbek M1, Baysal A1, Çulha M2. Colloids Surf B Biointerfaces. 2014 ;121:106-13.

1Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad, Ataşehir, Istanbul 34755, Turkey.and

2Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, Kayisdagi Cad, Ataşehir, Istanbul 34755, Turkey. Electronic address: [email protected]

Abstract

The toxicity of nanoparticles (NPs) depends on several factors including size, shape, surface properties and chemical nature of the NPs. The release of toxic ions due to the dissolution of nanoparticles is another important factor. In addition, impurities or reaction products from synthesis procedures on the nanoparticles surfaces may contribute to the toxicity. Zinc oxide nanoparticles (ZnO NPs) are one of the unique nanoparticles showing toxicity through all of these mentioned factors. In this study, we demonstrate that the treatment of the zinc oxide nanoparticles with hydrogen peroxide (H2O2) alters the surface properties of the zinc oxide nanoparticles by decomposing organic impurities remained from synthesis procedures. The changes on the surface chemistry and properties of the zinc oxide nanoparticles influence their behavior in cell culture media and the nanoparticles-cell interactions. Finally, a decrease in the cytotoxicity of H2O2 treated zinc oxide nanoparticles is observed on HDF and A549 cells through the decrease of the membrane damage and oxidative stress.

Copyright © 2014 Elsevier B.V. All rights reserved.

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Research on zinc oxide nanoparticles is featured on Global Medical Discovery the World’s leading source of medical research news