Home » Key Nanotechnology Articles » Enhanced biocompatibility for plasmid DNA on patterned TiO2 surfaces

Enhanced biocompatibility for plasmid DNA on patterned TiO2 surfaces

DNA compatability

Subrata Majumder, I. Mishra, U. Subudhi, Shikha Varma

Appl. Phys. Lett. 103, 063103 (2013)

 

Institute of Physics, Bhubaneswar 751005, India and

Department of Bioresources Engineering, IMMT, Bhubaneswar 751005, India

 

Abstract

 

 

An enhanced biocompatibility from nanodot patterned TiO2 surfaces, fabricated by ion beam sputtering, has been observed here through its interaction with plasmid DNA. Investigations of the persistence length and the areal conformation of DNA show that the biocompatibility increases with ion fluence. Presence of nanostructures and increased surface roughness, in conjugation with higher oxygen vacancy sites that promote charge transfer from DNA moiety, are responsible for the increased hydrophilicity and biocompatibility of the patterned surfaces.

© 2013 AIP Publishing LLC

 

Go to PubMed