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Bioinspired Patterning with Extreme Wettability Contrast on TiO2 Nanotube Array Surface: A Versatile Platform for Biomedical Applications.

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Extremely high contrast wetting surface with erasable and rewritable property has recently attracted intense interest due to its significance in basic research and technical applications. We have recently shown that a facile in-situ ink-regulating approach can be applied for rapidly reversible water wettability and adhesion transition with a large degree of contrast. This finding provides new strategies in the design of site-selective, sticky superhydrophobic patterns for droplet manipulation and cell immobilization (Advanced Materials, 2013, 25(12), 1682, Cover story). In this work, we describe a facile approach to construct erasable and rewritable superhydrophilic–superhydrophobic patterns on novel TiO2 nanotube arrays by a combination of photocatalytic lithography and self-assembly process. The patterned superhydrophobic surface is an excellent 2D scaffold for site-selective cell adhesion and reversible protein absorption, and acts as a template to deposit or grow 3D spatially functional biomaterials (e.g., CaP, Ag, biological molecules, and drugs) in a highly selective manner. Furthermore, the functional composite patterning would be a versatile platform for biochips, sensors, antibacterial agents, targeted drug delivery and cell bioassays. We envision that these combined processes and findings will aid in the development of novel functional nanomaterials with custom-tailored surface hydrophobicity and pattern for patterning template.


Figure Legend:

SEM image of a typical TiO2 nanotube array film on titanium substrate by electrochemical anodizing in 0.5 mass % HF solution (a). The corresponding cross-sectional SEM image of the film (b). Optical (c) and fluorescent (d) microscopy image of the superhydrophilic-superhydrophobic micropattern. The integrated advantages of high contrast wettability patterns on TiO2 nanotube array materials for various biomedical applications (e).


Bioinspired Patterning with Extreme Wettability Contrast on TiO(2) Nanotube Array SurfaceA Versatile Platform for Biomedical Applications.

Lai Y, Lin L, Pan F, Huang J, Song R, Huang Y, Lin C, Fuchs H, Chi L.

Small. 2013 Sep 9;9(17):2945-53.

Physikalisches Institute and Center for Nanotechnology (CeNTech), Westfälische Wilhelms-Universität Münster, Münster D-48149, Germany; National Engineering Laboratory of Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, PR China. [email protected].




Binary wettability patterned surfaces with extremely high wetting contrasts can be found in nature on living creatures. They offer a versatile platform for microfluidic management. In this work, a facile approach to fabricating erasable and rewritable surface patterns with extreme wettability contrasts (superhydrophilic/superhydrophobic) on a TiO2 nanotube array (TNA) surface through self-assembly and photocatalytic lithography is reported. The multifunctional micropatterned superhydrophobic TNA surface can act as a 2D scaffold for site-selective cell immobilization and reversible protein absorption. Most importantly, such a high-contrast wettability template can be used to construct various well-defined 3D functional patterns, such as calcium phosphate, silver nanoparticles, drugs, and biomolecules in a highly selective manner. The 3D functional patterns would be a versatile platform in a wide range of applications, especial for biomedical devices (e.g., high-throughput molecular sensing, targeted antibacterials, and drug delivery). In a proof-of-concept study, the surface-enhanced Raman scattering and antibacterial performance of the fabricated 3D [email protected] pattern, and the targeted drug delivery for site-specific and high-sensitivity cancer cell assays was investigated.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


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