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Probing o-diphenylphosphanyl benzoate (o-DPPB)-directed C-C bond formation: total synthesis of dictyostatin

Wünsch S, Breit B. Chemistry. 2015;21(6):2358-63.

Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg im Breisgau (Germany).

Abstract

Herein, we report a robust total synthesis of dictyostatin. This polyketide natural product has attracted much attention because of its impressive antiproliferative activity against several human cancer-cell lines. We accomplished its synthesis in a highly convergent manner from three fragments of equal complexity, which were prepared on multigram scale. The southern and northwestern subunits were constructed through application of our o-DPPB-directed hydroformylation and allylic substitution methodology, respectively. These methods generated the C6 and C14 stereocenters of dictyostatin with good diastereoselectivities and simultaneously allowed further elaboration of the fragments by Wittig olefination and Sharpless asymmetric epoxidation, respectively. The compelling performance of the hydroformylation and allylic substitution with regard to practicability, selectivity, and scale underline their value for the construction of propionate motifs.

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Probing o-diphenylphosphanyl benzoate (o-DPPB)-directed C-C bond formation: total synthesis of dictyostatin. Global Medical Discovery