Home » Key Drug Discovery Articles » HMG-CoA reductase inhibitors pravastatin, lovastatin and simvastatin suppress delayed rectifier K(+)-channel currents in murine thymocytes.

HMG-CoA reductase inhibitors pravastatin, lovastatin and simvastatin suppress delayed rectifier K(+)-channel currents in murine thymocytes.

Kazama I1, Baba A2, Maruyama Y2.

Pharmacol Rep. 2014 Aug;66(4):712-7.

1Department of Physiology I, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Electronic address: [email protected] and

2Department of Physiology I, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

 

Abstract

 

BACKGROUND:

Since lymphocytes predominantly express delayed rectifier K(+)-channels (Kv1.3) that trigger lymphocyte activation, statins, which exert immunosuppressive effects, would affect the channel currents.

METHODS:

Employing the patch-clamp technique in murine thymocytes, we examined the effects of statins on Kv1.3-channel currents and the membrane capacitance (Cm).

RESULTS:

Pravastatin significantly suppressed the pulse-end currents of the channels. Lovastatin and simvastatin also suppressed the peakcurrents, significantly decreasing the Cm.

CONCLUSIONS:

This study demonstrated for the first time that statins inhibit thymocyte Kv1.3-channels. The slow inactivation patterns induced by lovastatin and simvastatin may be associated with their accumulation in the plasma membranes.

Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

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HMG-CoA reductase