Home » Key Drug Discovery Articles » 3,5,6,7,8,3′,4′-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

3,5,6,7,8,3′,4′-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model

Journal Reference

Neurochem Int. 2014 May;70:30-8.
Okuyama S1, Morita M2, Miyoshi K2, Nishigawa Y2, Kaji M2, Sawamoto A2, Terugo T2, Toyoda N2, Makihata N2, Amakura Y3, Yoshimura M3, Nakajima M2, Furukawa Y2.

1 Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan. Electronic address: [email protected]
2 Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.
3 Department of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan.

Abstract
The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that 3,5,6,7,8,3′,4′-heptamethoxyflavone, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus. These results suggest that 3,5,6,7,8,3′,4′-heptamethoxyflavone has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.
Copyright © 2014 Elsevier Ltd. All rights reserved.

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