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Serum biochemical changes in pre and post treatment of cervical cancer patients: a case control study

Significance Statement

Significant altered biochemical constituents, clinical enzymes and metals were identified in pre and post-treated cervical cancer patients. Upon the treatment some biochemical constituents and clinical enzymes were revert to normal condition and some are may not, indicated that some of these biochemical parameters may be considered as prognostic indicators in response to radio therapy.

 

 

Effect of concurrent radio-chemotherapy and chemotherapy on seru

Dasari S1, Shouri RN2, Rajendra W3, Valluru L4.

Biomed Pharmacother. 2014 Apr;68(3):315-20.

1Department of Biotechnology, Dravidian University, Kuppam-517 426, A.P, India and

2Department of Radiation Oncology, Government General Hospital, Guntur, A.P, India and

3Department of Zoology, Sri Venkateswara University, Tirupati, A.P, India and

4Department of Biotechnology, Dravidian University, Kuppam-517 426, A.P, India. Electronic address: [email protected]

 

Abstract:

Objectives: Cervical cancer is most common in gynaecological cancers and it is not possible to detect the malignancy at early stage. Hence, it is important to study and asses the biochemical changes in pre and post- treated cervical cancer patients.

Methods: In the present study, appraise the serum biochemical constituents and clinical enzymes in pre and post treatment of cervical cancer. In the present investigation, 50 patients with cervical cancer were compared to suspected (n=25) and healthy controls (n=25). Of the 50, 25 patients were undergoing radiotherapy along with chemotherapy and 25 patients undergoing chemotherapy alone. Blood samples were collected from pre and post treatments of all the groups and estimated the level of serum biochemical constituents like serum proteins, albumin, globulins, cholesterol, bilirubin and uric acid; clinical enzymes includes serum alkaline phosphatase, alanine amino transferase, aspertate amino transaminase and lactate dehydrogenase; serum metals like selenium, zinc, copper and manganese.

Results: Serum biochemical constituents like total protein, albumin, globulin, cholesterol; clinical enzymes and metals like copper were increased significantly and bilirubin, uric acid, metals like selenium, zinc and manganese were decreased significantly in cervical cancer patients when compared with healthy cases. The post treatment values of these biochemical changes are variable depending upon the treatment.

Conclusion: In conclusion an admirable vicissitudes were observed during pre and post treatment of serum biochemical changes which may help to detect the disease and monitor the efficacy of treatment.