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The effect of vitamin D supplements on the severity of restless legs syndrome.

Wali S, Shukr A, Boudal A, Alsaiari A, Krayem A.

Sleep Breath. 2014 Aug 23.

Sleep Medicine and Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, [email protected]




Clinical observation hinted improved symptoms of restless legs syndrome (RLS) after vitamin D  supplements.  Hence, the aim of this study is to evaluate the effect of vitamin D supplementation on the severity of RLS symptoms.


Twelve adult subjects diagnosed with primary RLS and vitamin D deficiency were recruited. Patients with secondary RLS were excluded from this study. The complete cell count; serum levels of ferritin, iron, glycated hemoglobin, and vitamin D3 (25 (OH) vitamin D); and renal and bone profiles of the patients were assayed. Patients with vitamin D deficiency (<50 nmol/l) were treated with vitamin D3  supplements (high oral dose or intramuscular injection). The severity scores of RLS were reassessed after the vitamin D3 level was corrected to >50 nmol/l and compared with those before the administration of the supplements.


The median pretreatment vitamin D level was 21.7 nmol/l (13.45-57.4), which improved to 61.8 nmol/l (42.58-95.9) (P = 0.002) with the treatment. The median RLS severity score improved significantly from 26 (15-35) at baseline to 10 (0-27) after correction of the vitamin D levels (P = 0.002).


This study indicates that vitamin D supplementation improves the severity of RLS symptoms and advocates that vitamin Ddeficiency is conceivably associated with RLS.

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