Inhibition of GTPase Rac1 in endothelium by 6-mercaptopurine results in immunosuppression in nonimmune cells: new target for an old drug October 17, 2014 Read More »
A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: G protein-coupled receptors October 17, 2014 Read More »
KV7 potassium channels: a new therapeutic target in smooth muscle disorders October 17, 2014 Stott JB1, Jepps TA1, Greenwood IA2. Drug Discov Today. 2014 Apr;19(4):413-24. Read More »
High- and low-affinity sites for sodium in delta-OR-G(i)1 alpha (Cys(351)-Ile(351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane October 17, 2014 Vošahlíková, Miroslava – Jurkiewicz, Piotr – Roubalová, Lenka – Hof, Martin – Svoboda, Petr. Naunyn-Schmiedeberg’s Archives of Pharmacology. Roč. 387, č. 5 (2014), s. 487-502. Read More »
EBC-219: a new diterpene skeleton, crotinsulidane, from the Australian rainforest containing a bridge headdouble bond. October 17, 2014 Maslovskaya LA, Savchenko AI, Krenske EH, Pierce CJ, Gordon VA, Reddell PW, Parsons PG, Williams CM. Angew Chem Int Ed Engl. 2014 Jul 1;53(27):7006-9. Read More »
Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA. October 11, 2014 Read More »
Edoxaban transport via P-glycoprotein is a key factor for the drug’s disposition. October 11, 2014 Mikkaichi T, Yoshigae Y, Masumoto H, Imaoka T, Rozehnal V, Fischer T, Okudaira N, Izumi T. Drug Metab Dispos. 2014 Apr;42(4):520-8. Read More »
Calcium channel blockers and prostate cancer. October 11, 2014 Loughlin KR. Urol Oncol. 2014 Jul;32(5):537-8. Read More »
Development of new antiatherosclerotic and antithrombotic drugs utilizing F11 receptor (F11R/JAM-A) peptides October 11, 2014 Babinska A, Clement CC, Swiatkowska M, Szymanski J, Shon A, Ehrlich YH, Kornecki E, Salifu MO. Biopolymers. 2014 Apr;101(4):322-34. Read More »
Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells. October 5, 2014 Sun J, Knickelbein K, He K, Chen D, Dudgeon C, Shu Y, Yu J, Zhang L. Mol Cancer Ther. 2014 May;13(5):1298-308. Read More »
Emodin, an anthraquinone derivative, protects against gamma radiation-induced toxicity by inhibiting DNA damage and oxidative stress. October 5, 2014 Sharma R, Tiku AB. Int J Radiat Biol. 2014 Apr;90(4):275-83. Read More »
A Wickerhamomyces anomalus killer strain in the malaria vector Anopheles stephensi October 5, 2014 Read More »
Inhibition of glutathione synthesis distinctly alters mitochondrial and cytosolic redox poise October 1, 2014 Kolossov VL, Hanafin WP, Beaudoin JN, Bica DE, DiLiberto SJ, Kenis PJ, Gaskins HR. Exp Biol Med (Maywood). 2014 Apr;239(4):394-403. Read More »
A novel berbamine derivative inhibits cell viability and induces apoptosis in cancer stem-like cells of human glioblastoma, via up-regulation of miRNA-4284 and JNK/AP-1 signaling October 1, 2014 Yang F1, Nam S2, Brown CE3, Zhao R2, Starr R3, Ma Y, Xie J, Horne DA2, Malkas LH4, Jove R5, Hickey RJ6. PLoS One. 2014 Apr 14;9(4):e94443. Read More »
Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy. September 24, 2014 Hiatt A, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly MH, Velasco J, Whaley KJ, Piedra PA, Gilbert BE, Zeitlin L. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5992-7. Read More »
Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity September 19, 2014 Read More »
Degeneration and dysfunction of retinal neurons in acute ocular hypertensive rats: involvement of calpains. September 7, 2014 Suzuki R, Oka T, Tamada Y, Shearer TR, Azuma M. J Ocul Pharmacol Ther. 2014 Jun;30(5):419-28. Read More »
QSAR guided semi-synthesis and in-vitro validation of anticancer activity in ursolic acid derivatives. August 31, 2014 Kalani K, Yadav DK, Singh A, Khan F, Godbole MM, Srivastava SK. Curr Top Med Chem. 2014;14(8):1005-13. Read More »
Cytotoxic properties of D-gluco-, D-galacto- and D-manno-configured 2-amino-2-deoxy-glycerolipids against epithelial cancer cell lines and BT-474 breast cancer stem cells. August 31, 2014 Samadder P1, Xu Y2, Schweizer F3, Arthur G4. Eur J Med Chem. 2014 May 6;78:225-35. Read More »
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