Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. March 23, 2015 Mensa B1, Howell GL1, Scott R2, DeGrado WF3. Antimicrob Agents Chemother. 2014 ;58(9):5136-45. Read More »
Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis March 11, 2015 Read More »
Identification and Characterization of ML352: A Novel, Noncompetitive Inhibitor of the Presynaptic Choline Transporter. March 11, 2015 Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, Wu M, Li M, Daniels JS, Lindsley CW, Hopkins CR, Blakely RD. ACS Chem Neurosci. 2015 Feb 2. Read More »
Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors. March 11, 2015 Bhat R1, Adam AT1, Lee JJ1, Deloison G2, Rouillé Y3, Séron K4, Rotella DP5. Bioorg Med Chem Lett. 2014;24(17):4162-5. Read More »
A cell-surface β-hydroxylase is a biomarker and therapeutic target for hepatocellular carcinoma. March 11, 2015 Aihara A, Huang CK, Olsen MJ, Lin Q, Chung W, Tang Q, Dong X, Wands JR. Hepatology. 2014 ;60(4):1302-13. Read More »
MIF antagonist (CPSI-1306) protects against UVB-induced squamous cell carcinoma March 5, 2015 Read More »
Paricalcitol, a vitamin d receptor activator, inhibits tumor formation in a murine model of uterine fibroids March 5, 2015 Read More »
Protective effects of novel metal-nonoates on the cellular components of the vascular system March 5, 2015 Monti M, Solito R, Puccetti L, Pasotti L, Roggeri R, Monzani E, Casella L, Morbidelli L. J Pharmacol Exp Ther. 2014 Dec;351(3):500-9. Read More »
Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives March 5, 2015 Biochim Biophys Acta. 2014;1840(9):2970-7. Yue Wu1, Li-Peng Zan1, Xiao-Dong Wang1, Yu-Jing Lu2, Tian-Miao Ou1, Jing Lin1, Zhi-Shu Huang1, Lian-Quan Gu1 Read More »
Pituitary adenylate cyclase-activating polypeptide protects against {Beta}-amyloid toxicity February 27, 2015 Read More »
Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent. February 27, 2015 Read More »
Hyperthermia inhibits recombination repair of gemcitabine-stalled replication forks February 18, 2015 Read More »
Indimicins A-E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032 February 10, 2015 Read More »
Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. February 10, 2015 Vivares A, Salle-Lefort S, Arabeyre-Fabre C, Ngo R, Penarier G, Bremond M, Moliner P, Gallas JF, Fabre G, Klieber S. Xenobiotica. 2015 Jan;45(1):29-44. Read More »
Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice. February 10, 2015 Noguchi S, Yatera K, Wang KY, Oda K, Akata K, Yamasaki K, Kawanami T, Ishimoto H, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H. Respir Res. 2014 5;15:92. Read More »
PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells February 5, 2015 Read More »
MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1 February 5, 2015 Read More »
Stabilization of apoptotic cells: generation of zombie cells. January 27, 2015 Oropesa-Ávila M1, Andrade-Talavera Y2, Garrido-Maraver J1, Cordero MD3, de la Mata M1, Cotán D1, Paz MV1, Pavón AD1, Alcocer-Gómez E1, de Lavera I1,Lema R1, Zaderenko AP4, Rodríguez-Moreno A2, Sánchez-Alcázar JA1. Cell Death Dis. 2014 ;5:e1369. Read More »
Three types of cytotoxic natural caged-scaffolds: pure enantiomers or partial racemates January 19, 2015 Read More »
Ribosome display and photo-cross-linking techniques for in vitro identification of target proteins of bioactive small molecules. January 19, 2015 Wada A, Hara S, Osada H. Anal Chem. 2014 ;86(14):6768-73. Read More »
Global Medical Discovery Global Medical Discovery the World’s leading source of medical research news: featuring the medical discoveries and innovations that will lead to a brighter tomorrow
