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Key Drug Discovery Articles

Indoxyl sulfate suppresses hepatic fetuin-A expression via the aryl hydrocarbon receptor in HepG2 cells.

Journal Reference Nephrol Dial Transplant. 2015 Oct;30(10):1683-92.  Ochi A1, Mori K1, Nakatani S1, Emoto M1, Morioka T1, Motoyama K1, Fukumoto S1, Imanishi Y1, Shoji T2, Ishimura E1, Inaba M1.   Abstract BACKGROUND: Fetuin-A is a liver-derived circulating protein that has potent calcification-inhibitory activity. Uraemic patients exhibit decreased serum fetuin-A levels, increased vascular calcification and elevated cardiovascular mortality. Because the mechanisms ... Read More »