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Finally, A Cure for Hepatitis C!

Globally, about 170 million people are infected with hepatitis C; the disease kills 350,000 people annually. Approximately 4 million Americans are infected with hepatitis C. The prevalence of hepatitis C infection ranges from 0.4 to 3.5 per cent among the European member states. Often patients have no symptoms, so the majority of  infected people don’t know they are infected. The hepatitis C virus spreads by contact with infected blood, such as injection drug use, sexual contact or through blood transfusions. If left untreated, can progress to cirrhosis, liver cancer and liver failure.

Of the 7 major genotypes of hepatitis C, 1, 2 and 3 are the most common. In the USA, genotype 1 is the most common, while the most prevalent in Europe are genotypes 2 and 3. In the Indian subcontinent genotype 3 is the most common.


The Hepatitis C Cure

Until recently, treatment for hepatitis C fell into the good-but-not-great category, with only around 70 percent of patients being cured. And that was after as much as 48 weeks of a strict anti-viral drug regimen, including injections of interferon—which causes a number of debilitating side effects (loss of vision, sepsis, heart failure, and leucopenia.). Sofosbuvir is a much more potent killer of hepatitis C, with success in as many as 95 percent of patients. Even more, the medication only has to be administered for half of the time and has a remarkable safety profile.

Sofosbuvir is the first compound in the NS5B polymerase inhibitor class. It interferes with the virus’s ability to replicate and make proteins. Sofosbuvir, is offering impressive cure rates for Hepatitis C patients with two subtypes of the disease – 93% among those with genotype 2 and 61% among participants with genotype 3.
This is the first time in medical research that we have a cure for a viral disease. Both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) recommended approval of Sofosbuvir. The new potent antiviral drug combo (Sofosbuvir combination with ribavirin) may eventually replace interferon use for the majority of patients with hepatitis C.


Finally, A Cure for Hepatitis C! Global Medical Discovery