Multicompartment intracellular self-expanding nanogel for targeted delivery of drug cocktail.

Bahadur K C R, Xu P.

Adv Mater. 2012 Dec 18;24(48):6479-83.

Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 715 Sumter, Columbia, SC 29208, USA.


A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Multicompartment Intracellular Self-Expanding Nanogel for Targeted Delivery of Drug Cocktail